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Paper II — 2014 March (2010 Scheme) — Q7

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Paper II
2014 March (2010 Scheme) · 40 marks · 120 min

Question

Proton pump inhibitors

Q73 marksShort Notes

Answer

Examples: Omeprazole, Pantoprazole, Lansoprazole, Rabeprazole, Esomeprazole

Mechanism of action

  • Prodrugs, activated in the acidic environment of the parietal cell canaliculus
  • Irreversibly inhibit the H⁺/K⁺-ATPase (proton pump) on the luminal membrane of gastric parietal cells — the final common step of acid secretion
  • Produce profound and long-lasting suppression of both basal and stimulated gastric acid secretion

Uses

  • Peptic ulcer disease
  • GERD
  • Zollinger-Ellison syndrome
  • H. pylori eradication (as part of combination therapy)
  • NSAID-induced ulcer prophylaxis

Adverse effects

  • Generally well tolerated: headache, GI upset
  • Long-term use: increased risk of fractures (calcium malabsorption), vitamin B12 deficiency, hypomagnesaemia, increased risk of C. difficile infection and community-acquired pneumonia
  1. 1Peptic Ulcer Disease and Gastro oesophageal Reflux Disease

Other Years Asked

  1. 1(2023 July (Supplementary) (2019 Scheme)Short Essay · 8 marks
  2. 2Enumerate the drugs used in treatment of Peptic ulcer. Briefly describe any one group. Write one Helicobacter pylori eradication regimen. (6+2)2024 March (Supplementary) (2019 Scheme)Short Essay · 8 marks
  3. 3(2022 February (2019 Scheme)Short Essay · 8 marks
  4. 4(2023 July (Supplementary) (2010 Scheme)Essay · 6 marks
  5. 5Classify drugs used in treatment of Peptic ulcer. Describe briefly Omeprazole. (3+3)2024 August (Supplementary) (2010 Scheme)Essay · 6 marks
  6. 6Enumerate two drug groups used to treat peptic ulcer with two examples each. Write the mechanism of action of both groups. Write one H.pylori eradication regimen (2+2+2)2024 December (Supplementary) (2019 Scheme)Short Essay · 6 marks
  7. 7Read the case history and answer the following questions. Mr. Raman 32 years has developed severe epigastric pain after taking tab. Ibuprofen 400mg tds for his joint pain2014 September (Supplementary) (2010 Scheme)Essay · 6 marks
  8. 8(2023 January (Supplementary) (2019 Scheme)Short Essay · 5 marks
  9. 9Pharmacotherapy of Inflammatory Bowel Disease2022 February (2019 Scheme)Short Answer · 4 marks
  10. 10Proton pump inhibitors2015 February (2010 Scheme)Short Note · 3 marks
  11. 11Proton pump inhibitors2021 December (Supplementary) (2010 Scheme)Short Note · 3 marks
  12. 12H2 blockers2021 May (Supplementary) (2010 Scheme)Short Note · 3 marks
  13. 13Anti Helicobacter Pylori Drugs2024 March (Supplementary) (2010 Scheme)Short Note · 3 marks
  14. 14Peptic ulcer protective agents2018 July (Supplementary) (2010 Scheme)Short Note · 3 marks
  15. 15Proton pump inhibitors.2017 February (2010 Scheme)Short Note · 3 marks
  16. 16Omeprazole2020 February (Supplementary) (2010 Scheme)Short Note · 3 marks
  17. 17Omeprazole2025 August (Supplementary) (2010 Scheme)Short Note · 3 marks
  18. 18Rabeprazole.2015 September (Supplementary) (2010 Scheme)Short Note · 3 marks
  19. 19Lansoprazole2022 October (Supplementary) (2010 Scheme)Short Note · 3 marks
  20. 20Pantoprazole.2025 March (Supplementary) (2010 Scheme)Short Note · 3 marks
  21. 21Sucralfate in gastric ulcer2019 July (Supplementary) (2010 Scheme)Short Answer · 1 mark
  22. 22Comment on the interaction between itraconazole and omeprazole.2015 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  23. 23GERD.2015 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  24. 24Esomeprazole2021 May (Supplementary) (2010 Scheme)Short Answer · 1 mark
  25. 25Omeprazole is used in peptic ulcer – State reason2013 April (2010 Scheme)Short Answer · 1 mark
  26. 26Which of the following classes of drugs is most commonly used as the first-line pharmacologic treatment for GERD2025 March (Supplementary (SAY)) (2019 Scheme)MCQ (Case) · 1 mark
  27. 27Proton pump inhibitors2017 August (Supplementary) (2010 Scheme)Short Answer · 1 mark
  28. 28Peptic ulcer2016 October (Supplementary) (2010 Scheme)Short Answer · 1 mark
  29. 29H2 blockers2014 March (2010 Scheme)Short Answer · 1 mark
  30. 30Triple drug regimen in helicobacter pylori infection2018 February (2010 Scheme)Short Answer · 1 mark
  31. 31H.Pylori infection2013 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  32. 32Lansoprazole, amoxicillin and clarithromycin in H. pylori infection2019 February (2010 Scheme)Short Answer · 1 mark
  33. 33Proton pump inhibitors2019 February (2010 Scheme)Short Answer · 0.3 marks
  34. 34cimetidine is used in Peptic Ulcer Disease (PUD) Name the following (Two examples for each) (5x1=5)2023 March (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  35. 35Non systemic antacids.2022 July (Supplementary) (2019 Scheme)Short Answer · 0.2 marks

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