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Paper I — 2014 September (Supplementary) (2010 Scheme) — Q1

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Paper I
2014 September (Supplementary) (2010 Scheme) · 40 marks · 120 min

Question

Classify beta blockers with one example for each. Mention the therapeutic uses and adverse effects of propranolol (2+2+2=6)

Q16 marksEssays

Answer

Classification of beta blockers

  • Non-selective (β1 and β2): Propranolol
  • β1-selective (cardioselective): Atenolol
  • With additional α-blocking activity: Labetalol
  • With intrinsic sympathomimetic activity (partial agonist): Pindolol

Therapeutic uses of propranolol

  • Hypertension
  • Angina pectoris
  • Cardiac arrhythmias (supraventricular tachycardia)
  • Migraine prophylaxis
  • Essential tremor
  • Anxiety/performance anxiety (control of somatic symptoms)
  • Thyrotoxicosis (symptomatic control, adjunct in thyroid storm)

Adverse effects of propranolol

  • Bradycardia, heart block
  • Bronchospasm (non-selective — dangerous in asthmatics)
  • Fatigue, cold extremities (peripheral vasoconstriction)
  • Masking of hypoglycaemia symptoms in diabetics
  • Vivid dreams/nightmares, depression (lipophilic — crosses blood-brain barrier)
  • Rebound hypertension/angina with abrupt withdrawal
  • Worsening of heart failure if used in decompensated state
  1. 1Antiarrhythmic Drugs

Other Years Asked

  1. 1Enumerate β blockers. Explain any six uses and two contraindications of β blockers (2+3+1=6)2014 March (2010 Scheme)Essay · 6 marks
  2. 2Calcium channel blockers2013 April (2010 Scheme)Short Note · 3 marks
  3. 3Propranolol2022 May (Supplementary) (2010 Scheme)Short Note · 3 marks
  4. 4Supraventricular arrhythmias2014 March (2010 Scheme)Short Answer · 1 mark
  5. 5Assertion (A): Quinidine can cause QT prolongation. Reason (R): Class IA drugs have maximum sodium channel blocking effect.2025 March (Supplementary (SAY)) (2019 Scheme)MCQ (A/R) · 1 mark
  6. 6Verapamil in paroxysmal supra ventricular tachycardia2021 December (Supplementary) (2010 Scheme)Short Answer · 1 mark
  7. 7Assertion (A): Lignocaine is one of the preferred drugs in paroxysmal supraventricular tachycardia. Reason (R): Lignocaine is a blocker of inactivated Na+ channels more than that of open state. It is relatively selective for partially depolarized cells and those with longer action potential duration.2024 December (Supplementary) (2019 Scheme)MCQ · 1 mark
  8. 8Used in the treatment of atrial fibrillation2018 February (2010 Scheme)Short Answer · 1 mark
  9. 9Verapamil2022 May (Supplementary) (2010 Scheme)Short Answer · 1 mark
  10. 10Supra ventricular tachycardia.2014 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  11. 11Drugs for Paroxysmal Supra Ventricular Tachycardia (PSVT)2021 May (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  12. 12Nifedipine in supra ventricular arrhythmias Name the following (Two examples for each): (5x1=5)2023 July (Supplementary) (2010 Scheme)Short Answer · 0.3 marks

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