Paper II — 2013 September (Supplementary) (2010 Scheme) — Q1

Paper II

2013 September (Supplementary) (2010 Scheme) · 40 marks · 120 min

Question

Classify anti malarial drugs. Mention the adverse effects and therapeutic uses of chloroquine. (2+2+2=6)

Q16 marksEssays★✓

Answer

Classification of antimalarial drugs (by stage of action)

• Tissue schizonticides (causal prophylactics/radical cure): Primaquine (exoerythrocytic/hypnozoites), Proguanil
• Blood schizonticides: Chloroquine, Quinine, Artemisinin derivatives, Mefloquine, Sulfadoxine-pyrimethamine
• Gametocytocides: Primaquine (all species), Chloroquine (P. vivax/ovale/malariae only)
• Sporontocides: Proguanil, Primaquine

Adverse effects of chloroquine

• GI upset (nausea, vomiting)
• Pruritus (especially in dark-skinned individuals)
• Headache, blurring of vision
• Retinopathy and corneal deposits (with prolonged high-dose use)
• Cardiotoxicity (arrhythmias) with rapid IV administration
• Haemolysis in G6PD-deficient patients

Therapeutic uses of chloroquine

• Treatment of sensitive P. vivax, P. ovale, P. malariae, and sensitive P. falciparum malaria
• Malaria chemoprophylaxis
• Extraintestinal amoebiasis (hepatic amoebiasis)
• Rheumatoid arthritis, discoid/systemic lupus erythematosus (disease-modifying antirheumatic use)

Related Concepts

1. 1Antimalarial Drugs

Other Years Asked

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2. 2Classify Antimalarial drugs. Write the mechanism of action, therapeutic uses and adverse effects of Chloroquine. (3+3)2024 March (Supplementary) (2010 Scheme)Essay · 6 marks
3. 3o fever with chills for the past two days and diagnosed as a case of plasmodium falciparum malaria.2017 February (2010 Scheme)Essay · 6 marks
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8. 8Treatment of Chloroquine resistant falciparum malaria2024 June (Supplementary) (2019 Scheme)Short Answer · 4 marks
9. 9Artemisinin based combination therapy in Malaria2024 March (Supplementary) (2019 Scheme)Short Answer · 4 marks
10. 10Artemisinin based combination therapy (ACT ) in malaria2016 October (Supplementary) (2010 Scheme)Short Note · 3 marks
11. 11Chloroquine2025 August (Supplementary) (2010 Scheme)Short Note · 3 marks
12. 12Chloroquine2020 February (Supplementary) (2010 Scheme)Short Note · 3 marks
13. 13Artemisinin derivatives2019 July (Supplementary) (2010 Scheme)Short Note · 3 marks
14. 14Chloroquine2023 March (Supplementary) (2010 Scheme)Short Note · 3 marks
15. 15Chloroquine2017 August (Supplementary) (2010 Scheme)Short Note · 3 marks
16. 16Acyclovir2021 February (Supplementary) (2010 Scheme)Short Answer · 1 mark
17. 17Used in chloroquine resistant malaria2018 July (Supplementary) (2010 Scheme)Short Answer · 1 mark
18. 18Primaquine in plasmodium vivax malaria2022 May (Supplementary) (2010 Scheme)Short Answer · 1 mark
19. 19Primaquine in Vivax malaria2022 October (Supplementary) (2010 Scheme)Short Answer · 1 mark
20. 20Treatment of rheumatoid arthritis.2016 February (2010 Scheme)Short Answer · 1 mark
21. 21Treatment of multi drug resistant falciparum malaria2013 April (2010 Scheme)Short Answer · 1 mark
22. 22Sulphadoxine and pyrimethamine in malaria2020 February (Supplementary) (2010 Scheme)Short Answer · 1 mark
23. 23Chloroquine resistant malaria.2014 September (Supplementary) (2010 Scheme)Short Answer · 1 mark