Question
Primaquine in Vivax malaria
Q10 1 marks Short Answers ★ ✓
Answer
Plasmodium vivax forms dormant liver-stage hypnozoites, which blood schizonticides used to treat the acute attack cannot reach or kill, and which can reactivate weeks to months later to cause relapse. Primaquine is a tissue schizonticide specifically active against these hepatic hypnozoites, so it is added after acute treatment to achieve a radical cure — eliminating the dormant liver reservoir and preventing relapse. G6PD screening is mandatory before use, given its potent risk of triggering hemolysis in G6PD-deficient patients.
1 Antimalarial Drugs
Other Years Asked
1 ( 2022 July (Supplementary) (2019 Scheme) Short Essay · 8 marks 2 Classify Antimalarial drugs. Write the mechanism of action, therapeutic uses and
adverse effects of Chloroquine. (3+3) 2024 March (Supplementary) (2010 Scheme) Essay · 6 marks 3 o fever with chills for the past two days and
diagnosed as a case of plasmodium falciparum malaria. 2017 February (2010 Scheme) Essay · 6 marks 4 Classify drugs used in treatment of malaria. Explain the mechanism of action, adverse effects
and dose of any one such drug. Which drug is used for radical cure of acute vivax malaria. 2015 February (2010 Scheme) Essay · 6 marks 5 Read the case history and answer the following questions: An 18 years old boy was
brought to the outpatient department with history of fever with chills and shivering for
the past three days. Peripheral blood smear showed presence of intra erythrocytic
P.vivax parasite. (2+2+2)
Prescribe drugs treatment for the patient with dosage schedules.
Explain the mechanism of action of chloroquine.
What are the adverse effects of chloroquine when used for prolonged
period in large doses 2021 December (Supplementary) (2010 Scheme) Essay · 6 marks 6 An immigrant labourer comes to the hospital with fever, chills and rigor.
Peripheral smear showed malarial parasites. He was given chloroquine and primaquine.
Classify antimalarial drugs
Why are chloroquine and primaquine combined.
Explain the mechanism of action, uses and adverse effects of chloroquine.
List four drugs used for chloroquine resistant falciparum malaria. (2+1+2+1) 2021 February (Supplementary) (2010 Scheme) Essay · 6 marks 7 Classify anti malarial drugs. Mention the adverse effects and therapeutic uses of chloroquine.
(2+2+2=6) 2013 September (Supplementary) (2010 Scheme) Essay · 6 marks 8 How will you treat a case of malaria. What is the treatment given for relapse. Mention the drugs which can
be given to prevent malaria while visiting an endemic area. (2+2+2) 2024 December (Supplementary) (2019 Scheme) Short Essay · 6 marks 9 Treatment of Chloroquine resistant falciparum malaria 2024 June (Supplementary) (2019 Scheme) Short Answer · 4 marks 10 Artemisinin based combination therapy in Malaria 2024 March (Supplementary) (2019 Scheme) Short Answer · 4 marks 11 Artemisinin based combination therapy (ACT ) in malaria 2016 October (Supplementary) (2010 Scheme) Short Note · 3 marks 12 Chloroquine 2025 August (Supplementary) (2010 Scheme) Short Note · 3 marks 13 Chloroquine 2020 February (Supplementary) (2010 Scheme) Short Note · 3 marks 14 Artemisinin derivatives 2019 July (Supplementary) (2010 Scheme) Short Note · 3 marks 15 Chloroquine 2023 March (Supplementary) (2010 Scheme) Short Note · 3 marks 16 Chloroquine 2017 August (Supplementary) (2010 Scheme) Short Note · 3 marks 17 Acyclovir 2021 February (Supplementary) (2010 Scheme) Short Answer · 1 mark 18 Used in chloroquine resistant malaria 2018 July (Supplementary) (2010 Scheme) Short Answer · 1 mark 19 Primaquine in plasmodium vivax malaria 2022 May (Supplementary) (2010 Scheme) Short Answer · 1 mark 20 Treatment of rheumatoid arthritis. 2016 February (2010 Scheme) Short Answer · 1 mark 21 Treatment of multi drug resistant falciparum malaria 2013 April (2010 Scheme) Short Answer · 1 mark 22 Sulphadoxine and pyrimethamine in malaria 2020 February (Supplementary) (2010 Scheme) Short Answer · 1 mark 23 Chloroquine resistant malaria. 2014 September (Supplementary) (2010 Scheme) Short Answer · 1 mark 
