Question
Treatment of Chloroquine resistant falciparum malaria
Q11 4 marks Short Answers ★ ✓
Answer
Uncomplicated : full oral course of an Artemisinin-based Combination Therapy (ACT), e.g. Artemether + Lumefantrine — the artemisinin component rapidly reduces parasite biomass, the longer-acting partner clears remaining parasites.Severe/complicated : IV artesunate — current first-line, having replaced IV quinine after trial evidence of significant mortality reduction. IV quinine remains second-line where artesunate is unavailable, given by controlled infusion (never rapid push, given cardiotoxicity risk).Supportive care : careful fluid management (avoiding pulmonary edema), glucose monitoring/correction, and management of complications (renal replacement for AKI, ventilatory support for ARDS) as they arise.Once the patient tolerates oral therapy and the acute severe episode resolves, treatment is completed with a full oral ACT course.
1 Antimalarial Drugs
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