Question
Sulphadoxine and pyrimethamine in malaria
Q10 1 marks Short Answers ★ ✓
Answer
Sulfadoxine and pyrimethamine both act on the folate synthesis pathway of the malarial parasite, but at two sequential steps: sulfadoxine inhibits dihydropteroate synthase (blocking PABA incorporation into folate), while pyrimethamine inhibits dihydrofolate reductase (blocking conversion to the active tetrahydrofolate). This sequential dual blockade produces a synergistic antimalarial effect greater than either drug alone, and this combination (SP) is used as a partner drug in artemisinin-based combination therapy and for intermittent preventive treatment of malaria in pregnancy.
1 Antimalarial Drugs
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