Paper II — 2021 December (Supplementary) (2010 Scheme) — Q5

Paper II

2021 December (Supplementary) (2010 Scheme)

Question

Linezolid

Q53 marksShort Notes★✓

Answer

Linezolid is an oxazolidinone antibiotic.

Mechanism of action

• Binds to the 23S rRNA of the 50S ribosomal subunit, preventing formation of the initiation complex for bacterial protein synthesis (a unique mechanism, distinct from other protein synthesis inhibitors)

Spectrum/uses

• Active against Gram-positive organisms including MRSA and VRE (vancomycin-resistant enterococci)
• Reserved for multidrug-resistant Gram-positive infections

Adverse effects

• Thrombocytopenia/myelosuppression with prolonged use
• Peripheral/optic neuropathy (prolonged use)
• Serotonin syndrome (weak MAO inhibitor — caution with SSRIs)
• GI upset

Related Concepts

1. 1Macrolides and Other Antibacterials

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