Question
Mechanism of action of clarithromycin.
Q12 1 marks Short Answers ★ ✓
Answer
Clarithromycin, a macrolide antibiotic, binds reversibly to the 50S ribosomal subunit of susceptible bacteria, inhibiting bacterial protein synthesis by blocking translocation (movement of the ribosome along mRNA) — producing a bacteriostatic (occasionally bactericidal at high concentrations against very susceptible organisms) effect.
1 Macrolides and Other Antibacterials
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