Paper I — 2024 December (Supplementary) (2019 Scheme) — Qxx
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Paper I
2024 December (Supplementary) (2019 Scheme) · 100 marks · 180 min
Question
Which of the following immunoglobulins play a major role in this reaction
a) Ig A
b) Ig G
c) Ig E
d) Ig M
Long Essays. (2x10=20)
A 35 year old male complains of fever, fatigue for the past 15 days. He had bleeding gums for the past
3 days. He had severe bone pains also. His total white blood cell count was 1,23,000 cells/c.mm with
myeloblasts of 69%.
a) What is your provisional diagnosis.
b) Describe the peripheral smear and bone marrow findings.
c) What other investigations are to be done for classifying the disease and assessing the prognosis of the
patient. (1+4+5)
Define Apoptosis. Give examples of physiologic and pathologic conditions associated with Apoptosis.
Write in detail about mechanisms of Apoptosis. (1+2+7)
Short Essays. (6X6=36)
Cytokines in inflammation.
Paraneoplastic syndromes.
CSF findings in different types of meningitis
Factors affecting wound healing.
Haemophilia A
Explain the pathogenesis of septic shock.
Short Answers. (6x4=24)
Define and classify Embolism.
Lab diagnosis of Megaloblastic anaemia.
Informed consent.
Rickets – Aetiopathogenesis and manifestations.
Transfusion reactions.
Type II hypersensitivity reaction.
Qxx1 marksMCQs
Answer
IgE is the immunoglobulin class responsible for Type I hypersensitivity reactions. It binds with high affinity to Fc receptors on mast cells and basophils; upon re-exposure to the allergen (bee venom, in this scenario), cross-linking of the bound IgE triggers degranulation and the acute anaphylactic reaction described.
