Question
Adverse effects of aminoglycoside antibiotics
Q33 marksShort Notes
Answer
- Ototoxicity: Vestibular and auditory (irreversible), potentiated by concurrent loop diuretic use
- Nephrotoxicity: Reversible, non-oliguric renal impairment (proximal tubular accumulation)
- Neuromuscular blockade: Can precipitate/worsen weakness in myasthenia gravis, dangerous with anaesthetic muscle relaxants
- Hypersensitivity reactions (less common than beta-lactams)
- 1Aminoglycosides
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