Paper II — 2025 March (Supplementary) (2010 Scheme) — Q18

Paper II

2025 March (Supplementary) (2010 Scheme)

Question

Aminoglycoside antibiotics.

Q180.3 marksShort Answers★✓

Answer

Gentamicin, Amikacin (also Streptomycin, Tobramycin) — bind the bacterial 30S ribosomal subunit, causing misreading of mRNA and inhibiting protein synthesis; bactericidal against Gram-negative organisms, with nephrotoxicity and ototoxicity as their characteristic dose-limiting adverse effects.

Related Concepts

1. 1Aminoglycosides

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