Question
Adverse effects of aminoglycosides
Q43 marksShort Notes
Answer
- Ototoxicity: Both vestibular (dizziness, ataxia) and auditory (irreversible hearing loss) — dose-related, potentiated by loop diuretics
- Nephrotoxicity: Reversible, non-oliguric renal impairment due to accumulation in proximal tubular cells
- Neuromuscular blockade: Can precipitate/worsen weakness in myasthenia gravis, especially with anaesthetic muscle relaxants
- Hypersensitivity reactions (less common than with beta-lactams)
- 1Aminoglycosides
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