Question
Define inclusion bodies and give two examples
Q7 2 marks Short Notes ★ ✓
Answer
Inclusion bodies are distinct, microscopically visible structures forming within infected cells during certain viral infections, representing accumulations of viral particles/proteins/nucleic acid or altered host cell components.
Two examples :
Negri bodies — eosinophilic, round-to-oval intracytoplasmic inclusions found in neurons infected with rabies virus , classically in hippocampal pyramidal cells/cerebellar Purkinje cells; historically the classical diagnostic finding for rabies.Owl’s-eye inclusions — large, eosinophilic intranuclear inclusions with a surrounding halo, seen in cells infected with cytomegalovirus (CMV) .
(Other valid examples: Cowdry type A bodies — herpes simplex/varicella-zoster virus, intranuclear; Guarnieri bodies — vaccinia/variola, intracytoplasmic.)
1 Rabies
Other Years Asked
1 A 11-year-old girl, presented with history of agitation, delirium, abnormal behavior,
hallucinations, difficulty in swallowing liquids and fear of water. Her parents reported that
she was bitten by a stray dog on her right leg two months prior to presentation for which
she had received only oral antibiotics and injection tetanus toxoid. 2024 June (Supplementary) (2019 Scheme) Essay · 11 marks 2 Read the clinical history and answer the following questions:
A 27 years old male was admitted in intensive medical care unit with drooling of saliva
and fear for intake of liquids since morning. There was a past history of dog bite on
his right leg ten days back. 2016 February (2010 Scheme) Essay · 10 marks 3 A four-year-old child was brought to casualty with altered behavior and difficulty to
swallow liquids. Mother gave history of dog bite one month back and not taking
vaccine as per schedule 2024 August (Supplementary) (2010 Scheme) Essay · 10 marks 4 A 20 years old male patient was admitted in hospital with the complaints of difficulty in
swallowing liquids, loss of appetite and restlessness. He gave history of dog bite by
a street dog one month back.
What is the diagnosis of this condition
Discuss the pathogenesis
Describe the laboratory diagnosis of the condition
What are the post exposure prophylactic measures of this condition (1+3+3+3) 2021 February (Supplementary) (2010 Scheme) Essay · 10 marks 5 A 5-year-old boy was brought to pediatric casualty with irritability, agitation, abnormal
behaviour, difficulty in swallowing liquids and fear of water. His mother informed that he
had been bitten by a stray dog two months back. No medical help had been sought at
that time. 2024 March (Supplementary) (2019 Scheme) Essay · 10 marks 6 A four-year-old child was brought to paediatric casualty with fever, altered behaviour and
difficulty to swallow liquids. Mother gives a history of dog bite two months back and not
taking vaccine as per schedule.
( 2023 January (Supplementary) (2019 Scheme) Essay · 8 marks 7 Discuss the pathogenesis, antemortem lab diagnosis and post exposure prophylaxis of
Rabies. 2023 July (Supplementary) (2019 Scheme) Short Essay · 8 marks 8 Post exposure Prophylaxis for Rabies. 2022 May (Supplementary) (2010 Scheme) Short Essay · 5 marks 9 Rabies vaccines. 2025 March (Supplementary (SAY)) (2019 Scheme) Short Answer · 4 marks 10 Inclusion bodies 2021 May (Supplementary) (2010 Scheme) Short Note · 2 marks 11 Non-neural vaccines for rabies 2015 February (2010 Scheme) Short Note · 2 marks 12 Prophylaxis of rabies 2016 October (Supplementary) (2010 Scheme) Short Note · 2 marks 13 Pathogenesis of Rabies 2025 March (Supplementary) (2010 Scheme) Short Note · 2 marks 14 Inclusion bodies. 2019 February (2010 Scheme) Short Note · 2 marks 15 Negri bodies. 2013 September (Supplementary) (2010 Scheme) Short Note · 2 marks 16 Inclusion bodies. 2013 April (2010 Scheme) Short Note · 2 marks 17 Name the non-neural vaccines for preventing rabies and pre-exposure prophylaxis 2018 February (2010 Scheme) Short Note · 2 marks 18 Inclusion bodies 2025 August (Supplementary) (2010 Scheme) Short Note · 2 marks 19 Negri bodies 2019 July (Supplementary) (2010 Scheme) Short Note · 2 marks 20 Prophylaxis of rabies. 2013 April (2010 Scheme) Short Note · 2 marks 21 Rabies vaccines and latest schedule for immunization 2018 July (Supplementary) (2010 Scheme) Short Note · 2 marks 22 Rabies virus can be transmitted to humans by all of the following routes EXCEPT 2024 December (Supplementary) (2019 Scheme) MCQ · 1 mark 23 Name two zoonotic diseases. 2023 January (Supplementary) (2019 Scheme) 1 mark 24 Vaccine to prevent rabies in humans is 2024 December (Supplementary) (2019 Scheme) MCQ · 1 mark 25 An antemortem diagnostic method is 2024 December (Supplementary) (2019 Scheme) MCQ · 1 mark 
