Question
Pathogenesis of Rabies
Q6 2 marks Short Notes ★ ✓
Answer
Pathogenesis of rabies : rabies virus is introduced into a bite wound in the saliva of an infected animal; it first replicates locally in muscle tissue, then enters peripheral nerve endings and travels retrograde along axons toward the CNS. Once in the CNS, it replicates extensively in neurons (producing Negri bodies , classically in hippocampal/Purkinje cells), causing severe encephalitis. From the CNS, the virus spreads centrifugally via peripheral nerves to the salivary glands (basis for further transmission) and other highly innervated tissues (cornea, skin). Hydrophobia results from painful pharyngeal/laryngeal muscle spasm triggered by attempts to swallow, related to brainstem involvement and autonomic dysregulation.
1 Rabies
Other Years Asked
1 A 11-year-old girl, presented with history of agitation, delirium, abnormal behavior,
hallucinations, difficulty in swallowing liquids and fear of water. Her parents reported that
she was bitten by a stray dog on her right leg two months prior to presentation for which
she had received only oral antibiotics and injection tetanus toxoid. 2024 June (Supplementary) (2019 Scheme) Essay · 11 marks 2 Read the clinical history and answer the following questions:
A 27 years old male was admitted in intensive medical care unit with drooling of saliva
and fear for intake of liquids since morning. There was a past history of dog bite on
his right leg ten days back. 2016 February (2010 Scheme) Essay · 10 marks 3 A four-year-old child was brought to casualty with altered behavior and difficulty to
swallow liquids. Mother gave history of dog bite one month back and not taking
vaccine as per schedule 2024 August (Supplementary) (2010 Scheme) Essay · 10 marks 4 A 20 years old male patient was admitted in hospital with the complaints of difficulty in
swallowing liquids, loss of appetite and restlessness. He gave history of dog bite by
a street dog one month back.
What is the diagnosis of this condition
Discuss the pathogenesis
Describe the laboratory diagnosis of the condition
What are the post exposure prophylactic measures of this condition (1+3+3+3) 2021 February (Supplementary) (2010 Scheme) Essay · 10 marks 5 A 5-year-old boy was brought to pediatric casualty with irritability, agitation, abnormal
behaviour, difficulty in swallowing liquids and fear of water. His mother informed that he
had been bitten by a stray dog two months back. No medical help had been sought at
that time. 2024 March (Supplementary) (2019 Scheme) Essay · 10 marks 6 A four-year-old child was brought to paediatric casualty with fever, altered behaviour and
difficulty to swallow liquids. Mother gives a history of dog bite two months back and not
taking vaccine as per schedule.
( 2023 January (Supplementary) (2019 Scheme) Essay · 8 marks 7 Discuss the pathogenesis, antemortem lab diagnosis and post exposure prophylaxis of
Rabies. 2023 July (Supplementary) (2019 Scheme) Short Essay · 8 marks 8 Post exposure Prophylaxis for Rabies. 2022 May (Supplementary) (2010 Scheme) Short Essay · 5 marks 9 Rabies vaccines. 2025 March (Supplementary (SAY)) (2019 Scheme) Short Answer · 4 marks 10 Inclusion bodies 2021 May (Supplementary) (2010 Scheme) Short Note · 2 marks 11 Non-neural vaccines for rabies 2015 February (2010 Scheme) Short Note · 2 marks 12 Prophylaxis of rabies 2016 October (Supplementary) (2010 Scheme) Short Note · 2 marks 13 Inclusion bodies. 2019 February (2010 Scheme) Short Note · 2 marks 14 Negri bodies. 2013 September (Supplementary) (2010 Scheme) Short Note · 2 marks 15 Define inclusion bodies and give two examples 2020 February (Supplementary) (2010 Scheme) Short Note · 2 marks 16 Inclusion bodies. 2013 April (2010 Scheme) Short Note · 2 marks 17 Name the non-neural vaccines for preventing rabies and pre-exposure prophylaxis 2018 February (2010 Scheme) Short Note · 2 marks 18 Inclusion bodies 2025 August (Supplementary) (2010 Scheme) Short Note · 2 marks 19 Negri bodies 2019 July (Supplementary) (2010 Scheme) Short Note · 2 marks 20 Prophylaxis of rabies. 2013 April (2010 Scheme) Short Note · 2 marks 21 Rabies vaccines and latest schedule for immunization 2018 July (Supplementary) (2010 Scheme) Short Note · 2 marks 22 Rabies virus can be transmitted to humans by all of the following routes EXCEPT 2024 December (Supplementary) (2019 Scheme) MCQ · 1 mark 23 Name two zoonotic diseases. 2023 January (Supplementary) (2019 Scheme) 1 mark 24 Vaccine to prevent rabies in humans is 2024 December (Supplementary) (2019 Scheme) MCQ · 1 mark 25 An antemortem diagnostic method is 2024 December (Supplementary) (2019 Scheme) MCQ · 1 mark 
