Question
An antemortem diagnostic method is
a) Negri bodies in brain by Immunohistochemistryc) Antibody detection in salivab) Antigen in corneal smear by immunofluorescenced) RNA in brain by RTPCR
Qii 1 marks MCQs ★ ✓
Answer
- [x] b) Antigen in corneal smear by immunofluorescence
Corneal impression smear examined by direct fluorescent antibody testing for viral antigen is a genuine antemortem diagnostic method for rabies. In contrast, Negri bodies detected by immunohistochemistry in brain tissue and RT-PCR for viral RNA in brain tissue are postmortem diagnostic methods, since brain tissue can only be obtained after death. (Antibody detection in saliva is not a standard/reliable antemortem test — saliva is tested for viral RNA/antigen or by virus isolation, not typically for antibody, since antibody in saliva is not a recognized diagnostic marker.)
1 Rabies
Other Years Asked
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she was bitten by a stray dog on her right leg two months prior to presentation for which
she had received only oral antibiotics and injection tetanus toxoid. 2024 June (Supplementary) (2019 Scheme) Essay · 11 marks 2 Read the clinical history and answer the following questions:
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