Paper I
2023 July (Supplementary) (2019 Scheme) · 100 marks · 180 min

Question

Aldosterone antagonist.

Q220.2 marksShort Answers

Answer

Spironolactone, Eplerenone — competitively block aldosterone at the mineralocorticoid receptor in the collecting duct, reducing Na⁺ reabsorption and K⁺ excretion; used in heart failure (mortality benefit), resistant hypertension, and cirrhotic ascites.

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