Paper I — 2017 August (Supplementary) (2010 Scheme) — Q7

Paper I

2017 August (Supplementary) (2010 Scheme) · 40 marks · 120 min

Question

Furosemide.

Q73 marksShort Notes★✓

Answer

Furosemide is a loop diuretic.

Mechanism of action

• Inhibits the Na⁺-K⁺-2Cl⁻ (NKCC2) cotransporter in the thick ascending limb of the loop of Henle
• Abolishes the medullary concentration gradient, causing marked natriuresis, kaliuresis, and loss of urinary concentrating ability

Uses

• Acute pulmonary oedema/left ventricular failure
• Chronic congestive cardiac failure
• Oedema (hepatic, renal, nephrotic syndrome)
• Acute renal failure
• Hypertension (with renal impairment)
• Hypercalcaemia

Adverse effects

• Hypokalaemia, hyponatraemia, hypomagnesaemia
• Hypotension, dehydration
• Ototoxicity
• Hyperuricaemia
• Hyperglycaemia
• Metabolic alkalosis

Related Concepts

1. 1Renal Pharmacology

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