Paper I — 2025 March (Supplementary (SAY)) (2019 Scheme) — Qxvii

Paper I

2025 March (Supplementary (SAY)) (2019 Scheme) · 100 marks · 180 min

Question

A 26 year old women with third degree burns developed septic shock. With 24hours she was bleeding from all needle puncture sites, with extensive ecchymoses and petechiae and GI Bleeding. Lab studies showed Hb- 6gm/dl., platelet count 64000/cu mm., PT 20 seconds, PTT 50 seconds and D-dimer Positive.

Which one of the following investigation is diagnostic

• a) Platelet Count
• b) Prothrombin time
• c) Thrombin Time
• d) D – dimer test

Qxvii1 marksMCQs (Case)★✓

Answer

Correct answer: d) D – dimer test

The D-dimer test is the most specific/diagnostic single investigation for DIC among those listed — it directly reflects both thrombin generation (fibrin formation) and plasmin generation (fibrinolysis of that fibrin), which is the pathognomonic combination in DIC. Platelet count, PT, and thrombin time are all abnormal in DIC but are non-specific, being deranged in many other bleeding disorders as well.

Related Concepts

1. 1Acute Leukaemia

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