Paper II — 2025 March (Supplementary (SAY)) (2019 Scheme) — Qii

Paper II

2025 March (Supplementary (SAY)) (2019 Scheme) · 100 marks · 180 min

Question

All are true about carcinoma endometrium EXCEPT

• a) Commonly seen in post menopausal women
• b) Unopposed estrogen stimulation leads to serous carcinoma
• c) Endometrioid type is associated with increased signaling through P13K/AKT pathway
• d) Serous carcinoma is aggressive than endometrioid type

Qii1 marksMCQs★✓

Answer

Correct answer: b) Unopposed estrogen stimulation leads to serous carcinoma

This statement is FALSE (the exception). Unopposed oestrogen stimulation (obesity, nulliparity, unopposed HRT, PCOS, etc.) leads to endometrial hyperplasia and the endometrioid (Type I) carcinoma pathway, not serous carcinoma. Serous carcinoma is a Type II carcinoma that arises independent of oestrogen stimulation, typically in an atrophic endometrium in older postmenopausal women, and is driven by TP53 mutations rather than the PTEN/PI3K-AKT pathway alterations seen in endometrioid carcinoma. Serous carcinoma is indeed more aggressive than endometrioid carcinoma (option d is a true statement).

Related Concepts

1. 1Acute Leukaemia

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