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Paper II — 2020 February (Supplementary) (2010 Scheme) — Q3

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Paper II
2020 February (Supplementary) (2010 Scheme)

Question

Inhaled corticosteroids

Q33 marksShort Notes

Answer

Examples: Budesonide, Beclomethasone, Fluticasone

Mechanism of action

  • Bind to intracellular glucocorticoid receptors in airway cells, modulating gene transcription to reduce airway inflammation (reduced cytokine production, decreased inflammatory cell infiltration, reduced mucosal oedema)
  • Delivered directly to the airway, minimizing systemic absorption/side effects compared to oral corticosteroids

Uses

  • Maintenance therapy in bronchial asthma and COPD (long-term control, not for acute attacks)

Adverse effects

  • Oral candidiasis (thrush) — reduced by rinsing mouth after use
  • Dysphonia (hoarseness)
  • Minimal systemic effects at recommended doses; growth suppression in children with high-dose long-term use
  1. 1Corticosteroids

Other Years Asked

  1. 1day2025 March (Supplementary (SAY)) (2019 Scheme)Essay · 10 marks
  2. 2Glucocorticosteroids2024 June (Supplementary) (2019 Scheme)Short Essay · 8 marks
  3. 3Corticosteroids.2022 July (Supplementary) (2019 Scheme)Short Essay · 8 marks
  4. 4Describe the therapeutic uses and adverse effects of Corticosteroids. (4+4)2022 February (2019 Scheme)Short Essay · 8 marks
  5. 5Classify corticosteroids. Describe the uses and adverse effects of glucocorticoids (2+2+2)2019 February (2010 Scheme)Essay · 6 marks
  6. 6Enumerate Four glucocorticoids. Explain the measures to minimize hypothalamo pituitary adrenal axis suppression. Discuss two other adverse drug reactions of glucocorticoid therapy. (2+3+1)2024 December (Supplementary) (2019 Scheme)Short Essay · 6 marks
  7. 7A 60 year old lady is suffering from rheumatoid arthritis and has been prescribed prednisolone. Answer the following:2013 April (2010 Scheme)Essay · 6 marks
  8. 8Explain the adverse effects and role of inhaled steroids in Bronchial asthma.2025 March (Supplementary (SAY)) (2019 Scheme)Short Answer · 4 marks
  9. 9Adverse effects of glucocorticoids2018 July (Supplementary) (2010 Scheme)Short Note · 3 marks
  10. 10Therapeutic uses of Corticosteroids2024 August (Supplementary) (2010 Scheme)Short Note · 3 marks
  11. 11Adverse effects of Corticosteroids2025 August (Supplementary) (2010 Scheme)Short Note · 3 marks
  12. 12Therapeutic uses of corticosteroids2023 July (Supplementary) (2010 Scheme)Short Note · 3 marks
  13. 13Mechanism of action of hydrocortisone2016 October (Supplementary) (2010 Scheme)Short Answer · 1 mark
  14. 14Prednisolone.2025 March (Supplementary) (2010 Scheme)Short Answer · 1 mark
  15. 15Prednisolone2022 October (Supplementary) (2010 Scheme)Short Answer · 1 mark
  16. 16Drugs used in inflammatory bowel disease2023 July (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  17. 17Drugs for psoriasis2019 July (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  18. 18Drugs acting through nuclear receptors2023 March (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  19. 19Drugs used in Psoriasis2023 March (Supplementary) (2010 Scheme)Short Answer · 0.3 marks

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