Paper II — 2016 October (Supplementary) (2010 Scheme) — Q10

Paper II

2016 October (Supplementary) (2010 Scheme) · 40 marks · 120 min

Question

Mechanism of action of hydrocortisone

Q101 marksShort Answers★✓

Answer

Hydrocortisone binds to intracellular glucocorticoid receptors; the drug-receptor complex translocates to the nucleus and binds glucocorticoid response elements (GRE) on DNA, modulating gene transcription — inducing anti-inflammatory proteins (e.g., lipocortin-1, which inhibits phospholipase A2 and reduces prostaglandin/leukotriene synthesis) and repressing pro-inflammatory genes (via NF-κB inhibition), producing its anti-inflammatory and immunosuppressive effects. It also has significant mineralocorticoid activity, contributing to sodium/water retention.

Related Concepts

1. 1Corticosteroids

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