What is the cytogenetic abnormality seen in Chronic Myeloid Leukemia
Q171 marks
Answer
The Philadelphia chromosome — a reciprocal translocation t(9;22)(q34;q11), which fuses the BCR gene (chromosome 22) with the ABL gene (chromosome 9), producing the constitutively active BCR-ABL tyrosine kinase fusion protein responsible for the pathogenesis of CML.
