Paper I — 2025 March (Supplementary (SAY)) (2019 Scheme) — Qiii

Paper I

2025 March (Supplementary (SAY)) (2019 Scheme) · 100 marks · 180 min

Question

Leukocyte alkaline phosphatase is markedly reduced in:

• a) Acute Lymphoblastic Leukaemia
• b) Acute Myeloblastic Leukaemia
• c) Chronic Myeloid Leukaemia
• d) Chronic Lymphocytic Leukaemia

Qiii1 marksMCQs★✓

Answer

Correct answer: c) Chronic Myeloid Leukaemia

Leukocyte alkaline phosphatase (LAP) score is characteristically markedly reduced/absent in CML (reflecting the abnormal, Philadelphia chromosome-driven neutrophils), which is a key laboratory feature used to distinguish CML from a benign leukemoid reaction (where LAP score is elevated).

Related Concepts

1. 1Chronic Myeloid Leukaemia

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