Paper I — 2024 June (Supplementary) (2019 Scheme) — Q13

Paper I

2024 June (Supplementary) (2019 Scheme) · 100 marks · 180 min

Question

Write the chromosomal abnormality in Chronic myeloid leukemia

Q131 marks★✓

Answer

Reciprocal translocation t(9;22)(q34;q11) — the Philadelphia chromosome, fusing the BCR gene (chromosome 22) with the ABL gene (chromosome 9), producing the BCR-ABL fusion oncoprotein with constitutive tyrosine kinase activity.

Related Concepts

1. 1Chronic Myeloid Leukaemia

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