Question
A 26 year old women with third degree burns developed septic shock. With 24hours she was bleeding from all needle puncture sites, with extensive ecchymoses and petechiae and GI Bleeding. Lab studies showed Hb- 6gm/dl., platelet count 64000/cu mm., PT 20 seconds, PTT 50 seconds and D-dimer Positive.
Fibrin degradation products have a) Potent anticoagulant effect b) Platelet aggregation effect c) Prothrombotic effect d) Endothelial activation effect Long Essays. (2x10=20) 2. A 50 year old person was admitted to the hospital with complaints of intermittent fever for the past two weeks. He underwent a surgical procedure. The surgical wound has not healed. On examination Febrile, Pulse rate – 102/mt, dyspnoea present, drowsy, urine output less than 100ml/ 24 hours. Blood sample sent for culture and sensitivity. CBC – Hemoglobin 8g/dl, total WBC count -18000/cmm. a) What is your provisional diagnosis b) Describe briefly the etiopathogenesis of this condition c) What are the various organ changes seen in this condition d) Enlist the stages of this condition (2+3+3+2) 3. Define Leukaemia. Classify Acute Myeloblastic Leukaemia as per WHO classification. Describe the peripheral smear and bone marrow findings with illustrations in a case of Acute Myeloid Leukaemia. (2+3+2+3) Short Essays. (6X6=36) 4. Type II hypersensitivity reaction 5. Role of Chemical Carcinogens 6. Laboratory Diagnosis of Thalassemia 7. Granulomatous inflammation 8. Opportunistic Infections 9. Factors Influencing Wound Healing Short Answers. (6x4=24) 10. Enlist two common indications and two absolute contraindications for bone marrow aspiration study 11. Enumerate four common laboratory tests done to confirm Multiple Myeloma 12. Enlist Four common types of Necrosis with suitable clinical examples 13. Name the four cardinal principles of Biomedical Ethics 14. Enlist four common anticoagulants used in a Hematology laboratory 15. Mention four common stains used to demonstrate Amyloid in the tissue
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- Define Leukaemia. Classify Acute Myeloblastic Leukaemia as per WHO classification. Describe the peripheral smear and bone marrow findings with illustrations in a case of Acute Myeloid Leukaemia. (2+3+2+
- Short Essays. (6X6=36)
- Type II hypersensitivity reaction
- Role of Chemical Carcinogens
- Laboratory Diagnosis of Thalassemia
- Granulomatous inflammation
- Opportunistic Infections
- Factors Influencing Wound Healing Short Answers. (6x4=24)
- Enlist two common indications and two absolute contraindications for bone marrow aspiration study
- Enumerate four common laboratory tests done to confirm Multiple Myeloma
- Enlist Four common types of Necrosis with suitable clinical examples
- Name the four cardinal principles of Biomedical Ethics
- Enlist four common anticoagulants used in a Hematology laboratory
- Mention four common stains used to demonstrate Amyloid in the tissues
Answer
Correct answer: a) Potent anticoagulant effect
Fibrin degradation products (generated by plasmin-mediated fibrinolysis of fibrin/fibrinogen) have a potent anticoagulant effect — they interfere with fibrin monomer polymerization and coat platelet surfaces, impairing normal platelet aggregation. This contributes significantly to the bleeding tendency seen in DIC, compounding the effect of consumed platelets and clotting factors.