Paper I — 2024 December (Supplementary) (2019 Scheme) — Qxiii
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Paper I
2024 December (Supplementary) (2019 Scheme) · 100 marks · 180 min
Question
Gram negative bacteria are inherently resistant to
a) Vancomycin
b) Gentamicin
c) Netilmicin
d) Tobramycin
(PTO)
Qxiii1 marksMCQs
Answer
- [x] a) Vancomycin
Vancomycin, a glycopeptide antibiotic, is too large a molecule to cross the outer membrane of Gram-negative bacteria via their porin channels, and Gram-negative bacteria are therefore intrinsically resistant to it — this is a fundamental structural limitation, not an acquired resistance mechanism. Gentamicin, Netilmicin, and Tobramycin are all aminoglycosides, a class of antibiotics that are generally effective against many Gram-negative bacteria (though individual acquired resistance can occur via aminoglycoside-modifying enzymes, efflux pumps, or ribosomal target alteration) — Gram-negative organisms are not intrinsically resistant to this class as a whole.
