Paper I — 2022 July (Supplementary) (2019 Scheme) — Q17

Paper I

2022 July (Supplementary) (2019 Scheme) · 100 marks · 180 min

Question

What is the cytogenetic abnormality seen in Burkitt Lymphoma.

Q171 marks★✓

Answer

Reciprocal translocation t(8;14)(q24;q32), which juxtaposes the MYC oncogene (chromosome 8) with the immunoglobulin heavy chain gene (chromosome 14), leading to constitutive MYC overexpression.

Related Concepts

1. 1Non Hodgkin Lymphoma

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