Paper II — 2023 January (Supplementary) (2019 Scheme) — Q20

Paper II

2023 January (Supplementary) (2019 Scheme) · 100 marks · 180 min

Question

Cyclin D1 amplification is a feature of which lymphoma.

Q201 marks★✓

Answer

Mantle cell lymphoma — characterized by the translocation t(11;14), which juxtaposes the CCND1 (Cyclin D1) gene with the immunoglobulin heavy chain gene, causing Cyclin D1 overexpression and driving uncontrolled cell cycle progression.

Related Concepts

1. 1Molecular Basis of Cancer

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