Question
(A): von Willebrand factor is synthesized by Hepatocytes (R): von Willebrand factor is a carrier protein for factor VIII a) Both A & R are correct and R is the reason for A b) Both A & R are correct but R is not reason for A c) A is correct R is incorrect d) A is incorrect R is correct
Answer
Correct answer: d) A is incorrect R is correct
A is incorrect, R is correct. Von Willebrand factor is synthesized by vascular endothelial cells and megakaryocytes, not hepatocytes (hepatocytes synthesize most other clotting factors, but not vWF). R is correct — vWF does act as a stabilizing carrier protein for factor VIII in the circulation, protecting it from premature degradation, in addition to its primary role in mediating platelet adhesion to the subendothelium.