Paper I — 2024 December (Supplementary) (2019 Scheme) — Q8

Paper I

2024 December (Supplementary) (2019 Scheme) · 100 marks · 180 min

Question

Compare and contrast: chlorpromazine and risperidone. (3+3)

Q86 marksShort Essays★✓

Answer

Compare and contrast: Chlorpromazine and Risperidone

Feature	Chlorpromazine (typical)	Risperidone (atypical)
Class	First-generation (typical) antipsychotic	Second-generation (atypical) antipsychotic
Mechanism	Predominantly D2 receptor antagonism	Combined 5-HT2A and D2 receptor antagonism
Efficacy — positive symptoms	Effective	Effective
Efficacy — negative symptoms	Poor	Better efficacy against negative symptoms
Extrapyramidal symptoms	High risk (potent D2 blockade)	Lower risk (though risperidone has more EPS than other atypicals at higher doses)
Sedation/anticholinergic effects	Prominent (also blocks H1, alpha-1, muscarinic receptors)	Comparatively less
Metabolic adverse effects	Present but less than newer atypicals	Weight gain, dyslipidemia — a class-wide atypical concern
Hyperprolactinemia	Present	Prominent — risperidone is a notable exception among atypicals for causing marked prolactin elevation
Other notable effects	Corneal/lens deposits, photosensitivity	—

Shared features: both are used for schizophrenia and other psychotic disorders; both act at least partly through D2 receptor blockade in the mesolimbic pathway for antipsychotic effect.

Related Concepts

1. 1Antipsychotic and Antimanic Drugs

Other Years Asked

1. 1Name two Atypical antipsychotics. What are the advantages of Atypical antipsychotics over Typical antipsychotics2024 March (Supplementary) (2010 Scheme)Short Note · 3 marks
2. 2Atypical antipsychotic agents2019 July (Supplementary) (2010 Scheme)Short Note · 3 marks
3. 3Haloperidol2019 February (2010 Scheme)Short Answer · 1 mark
4. 4Mention two uses and two adverse effects of chlorpromazine2013 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
5. 5Risperidone2023 July (Supplementary) (2010 Scheme)Short Answer · 1 mark
6. 6Clozapine.2025 March (Supplementary) (2010 Scheme)Short Answer · 1 mark
7. 7Atypical anti psychotics2022 May (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
8. 8Atypical antipsychotics.2025 August (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
9. 9Drugs used in bipolar disorder2024 March (Supplementary) (2019 Scheme)Short Answer · 0.2 marks
10. 10Drugs used to treat Acute Mania.2023 January (Supplementary) (2019 Scheme)Short Answer · 0.2 marks
11. 11Antipsychotics.2024 June (Supplementary) (2019 Scheme)Short Answer · 0.2 marks
12. 12Drugs used to treat Bipolar illness.2023 July (Supplementary) (2019 Scheme)Short Answer · 0.2 marks
13. 13Drugs used to treat Schizophrenia2022 February (2019 Scheme)Short Answer · 0.2 marks
14. 14Antipsychotic agents2022 July (Supplementary) (2019 Scheme)Short Answer · 0.2 marks