Paper II — 2025 March (Supplementary (SAY)) (2019 Scheme) — Qi

Paper II

2025 March (Supplementary (SAY)) (2019 Scheme) · 100 marks · 180 min

Question

Presence of tumour cells in an Indian file pattern is typical of

• a) Invasive lobular carcinoma
• c) Papillary carcinoma
• b) Medullary carcinoma
• d) Cribriform carcinoma

Qi1 marksMCQs★✓

Answer

Correct answer: a) Invasive lobular carcinoma

Invasive lobular carcinoma of the breast characteristically shows tumour cells infiltrating in a single-file (“Indian file”) linear pattern through the stroma, due to loss of E-cadherin expression (which normally mediates cell-cell adhesion), causing the cells to lack cohesion and invade individually rather than forming glandular structures.

Related Concepts

1. 1Neoplasia Nomenclature Classification and Anaplasia

Other Years Asked

1. 1A 50-year-old nulliparous female presents with a hard lesion of the right breast that she had noticed 2 weeks ago. Clinical examination reveals puckering of the overlying skin and retraction of the nipple along with a 3 cm hard mass in the upper outer quadrant of the right breast. 3 hard masses are palpable in the right axilla. On questioning the patient reveals a weight loss of 7kg in the last 2 months. Mammogram reveals a 3.4 cm mass with irregular spiculated margins and increased density compared to the surrounding breast tissue. (2022 February (2019 Scheme)Essay · 15 marks
2. 2Microscopy of this lesion will show all EXCEPT2025 March (Supplementary (SAY)) (2019 Scheme)MCQ · 1 mark