Paper I — 2025 March (Supplementary (SAY)) (2019 Scheme) — Qxviii
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Paper I
2025 March (Supplementary (SAY)) (2019 Scheme) · 100 marks · 180 min
Question
Assertion (A): Allopurinol can precipitate acute gout.
Reason (R): Inhibition of uric acid synthesis mobilizes tissue store of uric acid in to plasma.
Assertion) Allopurinol can precipitate acute gout.
Reason) Inhibition of uric acid synthesis mobilizes tissue store of uric acid in to plasma.
a) Both A and R are true, and R is the correct explanation of A
c) A is true but R is false
b) Both A and R are true, and R is not the correct explanation of A
d) A is false but R is true
Qxviii1 marksMCQs (A/R)
Answer
Correct answer: a) Both A and R are true, and R is the correct explanation of A
Both statements are true, and R correctly explains A: allopurinol can precipitate an acute gout attack when started, because inhibiting uric acid synthesis (via xanthine oxidase blockade) alters serum urate levels rapidly, mobilizing and destabilizing existing tissue urate crystal deposits into the plasma/joint space, triggering an inflammatory response — the reason allopurinol is never started during an acute attack, and is often co-started with colchicine/NSAID prophylaxis when initiated.
