Paper I
Question
Lipofuscin deposition is most likely due to
Answer
Correct answer: a) Autophagocytosis
Lipofuscin (“wear-and-tear” pigment) is an insoluble, brownish-yellow granular pigment composed of undigested lipid-protein complexes derived from lysosomal (autophagic) digestion of damaged intracellular organelles; it accumulates with ageing and free radical-mediated peroxidation of cell membranes, reflecting a byproduct of autophagocytosis rather than a cell death pathway.