Paper I
Question
The most common cause for male hypogonadism is
Answer
Correct answer: a) Klinefelter’s syndrome
Klinefelter syndrome (47,XXY) is the most common cause of male hypogonadism/infertility due to a chromosomal abnormality — testicular dysgenesis from the extra X chromosome causes hypergonadotropic hypogonadism. (Turner syndrome affects females; Down and Edward syndromes are autosomal trisomies not primarily associated with hypogonadism as their defining feature.)

