Paper I — 2024 March (Supplementary) (2019 Scheme) — Q17

Paper I

2024 March (Supplementary) (2019 Scheme) · 100 marks · 180 min

Question

Name TWO mechanisms of auto-immunity.

Q171 marks★✓

Answer

Two mechanisms of autoimmunity: Molecular mimicry (cross-reactivity between a microbial antigen and a structurally similar self-antigen, e.g., streptococcal M protein and cardiac tissue in rheumatic fever) and Release of sequestered (hidden) self-antigens (antigens normally sheltered from immune surveillance in immunologically privileged sites, released into circulation following trauma/infection, triggering an autoimmune response since central tolerance was never established against them).

Related Concepts

1. 1Autoimmunity

Other Years Asked

1. 1Discuss various mechanisms of autoimmunity.2024 December (Supplementary) (2019 Scheme)Short Essay · 6 marks
2. 2Pathogenesis of autoimmune diseases2015 September (Supplementary) (2010 Scheme)Short Essay · 5 marks
3. 3Name four autoimmune diseases.2023 March (Supplementary) (2010 Scheme)Short Note · 2 marks
4. 4Mention mechanisms of autoimmunity2017 August (Supplementary) (2010 Scheme)Short Note · 2 marks
5. 5Mechanisms of autoimmune disease2021 May (Supplementary) (2010 Scheme)Short Note · 2 marks
6. 6Super antigen with an example2015 February (2010 Scheme)Short Note · 2 marks
7. 7Write TWO mechanisms of autoimmunity2024 March (Supplementary) (2010 Scheme)Short Note · 2 marks
8. 8Name four autoimmune diseases2018 July (Supplementary) (2010 Scheme)Short Note · 2 marks
9. 9Immunological tolerance2015 February (2010 Scheme)Short Note · 2 marks