Paper I
Question
(A): Type-1 hypersensitivity reaction causes laryngeal edema (R): Histamine causes increased vascular permeability and pain
Answer
Correct answer: a) Both A & R are correct and R is the reason for A
Both statements are correct, and R is the reason for A. In Type I (IgE-mediated) hypersensitivity, mast cell degranulation releases histamine, which increases vascular permeability, causing fluid leakage into the interstitial tissue; when this occurs in the laryngeal mucosa (as in anaphylaxis), it produces laryngeal oedema, a life-threatening airway emergency.

