Paper I
2024 December (Supplementary) (2019 Scheme) · 100 marks · 180 min

Question

(A): Type-1 hypersensitivity reaction causes laryngeal edema (R): Histamine causes increased vascular permeability and pain

  • a) Both A & R are correct and R is the reason for A
  • b) Both A & R are correct but R is not reason for A
  • c) A is correct R is incorrect
  • d) A is incorrect R is correct (PTO)
Qxii1 marksMCQs

Answer

Correct answer: a) Both A & R are correct and R is the reason for A

Both statements are correct, and R is the reason for A. In Type I (IgE-mediated) hypersensitivity, mast cell degranulation releases histamine, which increases vascular permeability, causing fluid leakage into the interstitial tissue; when this occurs in the laryngeal mucosa (as in anaphylaxis), it produces laryngeal oedema, a life-threatening airway emergency.

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