Question
(A) Intestinal type of gastric adenocarcinoma present as polypoid bulky tumour (R) E-cadherin expression is lost in intestinal type of gastric adenocarcinoma
Answer
Correct answer: c) A is correct R is incorrect
Assertion (A) is correct — the intestinal type of gastric adenocarcinoma (Lauren classification) typically forms cohesive gland-forming structures, presenting as a bulky, polypoid or fungating, exophytic mass, often on a background of intestinal metaplasia. Reason (R) is incorrect — loss of E-cadherin expression (often due to CDH1 mutation) is the hallmark of the diffuse type, not the intestinal type, of gastric adenocarcinoma; this loss of cell adhesion causes diffuse type tumours to infiltrate as discohesive single cells/signet-ring cells rather than forming a bulky mass (producing the “linitis plastica” pattern).