Paper I
2022 May (Supplementary) (2010 Scheme) · 40 marks · 120 min
Question
Sodium valproate
Q43 marksShort Notes
Answer
Broad-spectrum antiepileptic. MOA: increases GABA levels (inhibits GABA transaminase), blocks voltage-gated Na⁺ channels, and blocks T-type Ca²⁺ channels (useful in absence seizures).
Uses: generalized tonic-clonic seizures, absence seizures, myoclonic seizures, bipolar disorder, migraine prophylaxis.
Adverse effects: hepatotoxicity, teratogenicity (neural tube defects — avoided in pregnancy), weight gain, tremor, alopecia, thrombocytopenia.
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