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Paper I — 2025 March (Supplementary (SAY)) (2019 Scheme) — Qxii

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Paper I
2025 March (Supplementary (SAY)) (2019 Scheme) · 100 marks · 180 min

Question

Mechanism of resistance to Isoniazid and Rifampicim in Mycobacterium tuberculosis is acquired to

  • a) Plasmid
  • b) Mutation
  • c) Transposon
  • d) Transduction (PTO)
Qxii1 marksMCQs

Answer

- [x] b) Mutation

Resistance to isoniazid and rifampicin in Mycobacterium tuberculosis is acquired through spontaneous chromosomal mutations (e.g., in the katG/inhA genes for isoniazid resistance, and the rpoB gene for rifampicin resistance), selected for under the pressure of inadequate/incomplete anti-tubercular treatment — this is the basis of Multi-Drug Resistant TB (MDR-TB, defined as resistance to at least isoniazid and rifampicin). Unlike many other bacteria, M. tuberculosis does not typically acquire resistance via plasmids, transposons, or transduction — horizontal gene transfer mechanisms are not the recognized basis of drug resistance in this organism.

  1. 1Tuberculosis (Microbiology)

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