Question
Metronidazole
Q7 3 marks Short Notes ★ ✓
Answer
Metronidazole is a nitroimidazole antimicrobial with combined antibacterial and antiprotozoal activity.
MOA : metronidazole → reduced by anaerobic/microaerophilic organisms’ ferredoxin-mediated electron transport → generates cytotoxic free-radical/nitroso intermediates → DNA strand breakage and cell death.
Uses : anaerobic bacterial infections, amoebiasis, giardiasis, trichomoniasis, H. pylori eradication, pseudomembranous (C. difficile ) colitis.
Adverse effects : metallic taste, nausea, peripheral neuropathy with prolonged use, disulfiram-like reaction with alcohol.
1 Antiamoebic Drugs
Other Years Asked
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