Paper II — 2024 December (Supplementary) (2019 Scheme) — Qxv

Paper II

2024 December (Supplementary) (2019 Scheme) · 100 marks · 180 min

Question

Diphtheria vaccine is a

• a) Subunit vaccine
• b) Toxoid vaccine
• c) Whole cell vaccine
• d) Recombinant vaccine Question numbers (xvi) – (xx) consists of two Statements-Assertion (A) and Reason (R). Answer these questions by selecting the appropriate options given below.

Qxv1 marksMCQs★✓

Answer

- [x] b) Toxoid vaccine

The diphtheria vaccine is a toxoid vaccine — diphtheria exotoxin is chemically inactivated (with formaldehyde) to remove its toxicity while retaining its immunogenicity, so that the immune response is directed against the toxin itself (neutralizing future toxin exposure), rather than against the whole bacterium. It is not a subunit vaccine (which would use a specific bacterial/viral protein antigen unrelated to toxin neutralization), whole cell vaccine (which uses the entire inactivated/killed organism), or recombinant vaccine (produced via genetic engineering, unrelated to the classical toxoid preparation method used for diphtheria).

Related Concepts

1. 1Diphtheria

Other Years Asked

1. 1A 10 years old boy was admitted in pediatric ward with history of fever, toxaemia and on examination. A white patch seen of fauces which bleeds on removal. He was not immunized properly. Answer the following:2014 September (Supplementary) (2010 Scheme)Essay · 10 marks
2. 2E cervical lymphadenopathy and white patch seen on the tonsil. (2022 July (Supplementary) (2019 Scheme)Essay · 9 marks
3. 3Discuss the pathogenesis and laboratory diagnosis of diphtheria2024 June (Supplementary) (2019 Scheme)Short Essay · 8 marks
4. 4Laboratory diagnosis and prophylaxis of Diphtheria2024 March (Supplementary) (2010 Scheme)Short Essay · 5 marks
5. 5Nagler reaction2021 February (Supplementary) (2010 Scheme)Short Note · 2 marks
6. 6Laboratory diagnosis of diphtheria2021 May (Supplementary) (2010 Scheme)Short Note · 2 marks
7. 7Eleke’s gel precipitation test2013 September (Supplementary) (2010 Scheme)Short Note · 2 marks
8. 8Nagler reaction.2016 February (2010 Scheme)Short Note · 2 marks
9. 9Pathogenesis of diphtheria2019 February (2010 Scheme)Short Note · 2 marks
10. 10Elek’s test2013 April (2010 Scheme)Short Note · 2 marks
11. 11Diphtheria toxin2019 July (Supplementary) (2010 Scheme)Short Note · 2 marks
12. 12What is the mechanism of action of the virulence factor in diphtheria.2022 February (2019 Scheme)1 mark