Paper I — 2023 July (Supplementary) (2019 Scheme) — Q10

Paper I

2023 July (Supplementary) (2019 Scheme) · 100 marks · 180 min

Question

Pharmacotherapy of Alcohol dependence.

Q104 marksShort Answers★✓

Answer

• Acute withdrawal: benzodiazepines (Diazepam/Lorazepam) to prevent/treat withdrawal seizures and delirium tremens; thiamine supplementation to prevent Wernicke’s encephalopathy.
• Relapse prevention/maintenance: Disulfiram (inhibits aldehyde dehydrogenase, causing an aversive acetaldehyde-accumulation reaction on alcohol intake), Naltrexone (opioid receptor antagonist, reduces alcohol’s rewarding effect/craving), Acamprosate (modulates glutamate/GABA, reduces craving).
• Psychosocial support/counseling alongside pharmacotherapy improves long-term outcomes.

Related Concepts

1. 1Ethyl and Methyl Alcohol

Other Years Asked

1. 1Rationale of ethanol in methanol poisoning.2016 February (2010 Scheme)Short Note · 3 marks
2. 2Treatment of methanol poisoning.2015 February (2010 Scheme)Short Answer · 1 mark
3. 3Explain the pharmacological basis for the use of ethyl alcohol in methanol poisoning.2017 August (Supplementary) (2010 Scheme)Short Answer · 1 mark
4. 4Ethyl alcohol in methyl alcohol poisoning2022 October (Supplementary) (2010 Scheme)Short Answer · 1 mark
5. 5Ethyl alcohol in Methyl alcohol poisoning.2025 March (Supplementary) (2010 Scheme)Short Answer · 1 mark
6. 6Fomepizole in methanol poisoning2021 February (Supplementary) (2010 Scheme)Short Answer · 1 mark
7. 7Rationale for use of ethanol in methanol poisoning2015 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
8. 8Mechanism of action of disulfiram2013 April (2010 Scheme)Short Answer · 1 mark
9. 9Fomepizole in methanol poisoning2019 July (Supplementary) (2010 Scheme)Short Answer · 1 mark
10. 10 Fomepizole in methyl alcohol poisoning2020 February (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
11. 11Drugs used for Alcohol deaddiction2022 February (2019 Scheme)Short Answer · 0.2 marks