Paper II
Question
(A) Hepatocytes show PASD positive cytoplasmic globular inclusions in Alpha -1 -Antitrypsin deficiency. (R) Alpha-1-Antitrypsin deficiency is caused by mutations that lead to misfolding of Alpha -1-Antitrypsin
Answer
Correct answer: a) Both A & R are correct and R is the reason for A
Both statements are correct, and R explains A. In α1-antitrypsin (AAT) deficiency, gene mutations (most commonly the Z allele) cause the AAT protein to misfold; the misfolded protein cannot be secreted from hepatocytes and instead accumulates within the endoplasmic reticulum, forming characteristic round-to-oval, PAS-positive, diastase-resistant (PASD-positive) cytoplasmic globular inclusions — directly explaining the histological finding in A.