Paper II
Question
Type I diabetes mellitus
- Associated with HLADR3, HLADR4 or both
- Autoimmune destruction of β cells occurs
- Most common in childhood
- Associated with central obesity a) 1, 2 and 3 are correct c) 1, 3 and 4 are correct b) 2, 3 and 4 are correct d) 1, 2 and 4 are correct
Answer
For reference, genuine features of Type 1 diabetes mellitus include: autoimmune (Type IV hypersensitivity, T-cell mediated) destruction of pancreatic islet beta cells, associated autoantibodies (anti-GAD65, anti-islet cell, anti-insulin), absolute insulin deficiency requiring exogenous insulin therapy, typical onset in childhood/young adulthood, association with certain HLA haplotypes (HLA-DR3/DR4), and susceptibility to diabetic ketoacidosis.