Nephrotic range proteinuria – Definition and common causes
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Answer
Definition
Nephrotic-range proteinuria is urinary protein excretion of ≥3.5 g/24 hours (in adults), the threshold that defines nephrotic syndrome when accompanied by hypoalbuminaemia, oedema, and hyperlipidaemia
Common causes
Primary glomerular diseases:
Minimal change disease (most common cause in children)
Focal segmental glomerulosclerosis
Membranous nephropathy (most common cause in adults)
Membranoproliferative glomerulonephritis
Secondary causes:
Diabetic nephropathy (most common secondary cause overall)
