Paper II
Question
Syndromes associated with Wilms tumour are
- WAGR
- Gardner
- Denys Drash
- Beckwith Wiedemann a) 1, 2, 3 b) 2, 3, 4 c) 3, 4, 1 d) 1, 2, 4 Question numbers (xi) – (xv) consists of two Statements - Assertion (A) and Reason (R). Answer these questions by selecting the appropriate options given below.
Answer
For reference, genuine syndromes associated with Wilms tumour include: WAGR syndrome (Wilms tumour, Aniridia, Genitourinary anomalies, Range of developmental delay — due to WT1 deletion on 11p13), Denys-Drash syndrome (WT1 mutation, causing gonadal dysgenesis and progressive nephropathy), and Beckwith-Wiedemann syndrome (WT2 locus on 11p15, causing organomegaly, macroglossia, and hemihypertrophy).

